The news was announced during a question and answer session with the writers on Twitter late Tuesday night: "BREAKING NEWS for those of you who are still here with us: Sarah Silverman will guest star in Episode 222."
Silverman started out on 'Saturday Night Live' in the early 1990s before moving on to 'The Mr. Show With Bob and David, 'eventuallly winding up with her Comedy Central show,' The Sarah Silverman Program, 'in 2007. Along the way she's had guest spots in shows ranging from 'Star Trek: Voyager' - she played Tom Paris's love interest! - To 'The Larry Sanders Show' and 'Monk.'